ChinaXiv.org 中国科学院科技论文预发布平台

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2025
1
2024
22

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result total 23.

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1. ChinaXiv:202501.00168
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In Vitro and in Vivo Drug Metabolism Analysis of BPI-460372, a Covalent TEAD1/3/4 Inhibitor

Subjects: Pharmaceutical Science >> Pharmacokinetics submitted time 2025-01-16

Liu, Xiaoyun Zhong, Dafang Tang, Chongzhuang Xu, Xiaofeng Lan, Hong Diao, Xingxing

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Hits 860 Downloads 253 Comment 0
2. ChinaXiv:202412.00349
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Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors

Subjects: Pharmaceutical Science >> Drug Design submitted time 2024-12-30

Wang, Xudong Xiong, Liwei Zhu, Ying Liu, Sixiu Zhao, Wenfeng Wu, Xinyuan Seydimemet, Mengnisa Li, Linjie Ding, Peiqi Lin, Xian Liu, Jiaxiang Wang, Xuan Duan, Zhiqiang Lu, Weiwei Suo, Yanrui Cui, Mengqing Yue, Jinfeng Jin, Rui Zheng, Mingyue Xu, Yechun

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Hits 1057 Downloads 287 Comment 0
3. ChinaXiv:202412.00352
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Enzyme-Sialylation-Controlled Chemical Sulfation of Glycan Epitopes for Decoding the Binding of Siglec Ligands

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-12-30

Ma, Shengzhou Zhang, Pengfei Ye, Jinfeng Tian, Yinping Tian, Xiao Jung, Jaesoo Macauley, Matthew S. Zhang, Jiabin Wu, Peng Wen, Liuqing

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Hits 1083 Downloads 312 Comment 0
4. ChinaXiv:202412.00350
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Chemoproteomics of Marine Natural Product Naamidine J Unveils CSE1L as a Therapeutic Target in Acute Lung Injury

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-12-30

Gao, Cheng-Long Song, Jin-Qian Yang, Ze-Nan Wang, Haojie Wu, Xin-Yuan Shao, Changwei Dai, Hong-Xia Chen, Kaixian Guo, Yue-Wei Pang, Tao Li, Xu-Wen

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Hits 1225 Downloads 331 Comment 0
5. ChinaXiv:202412.00336
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Mutation in CDC42 gene set as a response biomarker for immune checkpoint inhibitor therapy

Subjects: Pharmaceutical Science >> Genetics(Drug related) submitted time 2024-12-26

Wang, Kun Zhang, Yingying Su, Zhaoming Wang, Bei Zhou, Yuanyang Tong, Xiaochu Xie, Chengying Luo, Xiaomin Zhang, Sulin Zheng, Mingyue

Peer Review Status:Awaiting Review

Hits 1185 Downloads 247 Comment 0
6. ChinaXiv:202409.00182
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Difunctionalization of gem-difluoroalkenes for amination and heteroarylation via metal-free photocatalysis

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-09-20

Zhong, Yuanchen Zhuang, Zhen Zhang, Xiaofei Xu, Bin Yang, Chunhao

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Hits 1439 Downloads 538 Comment 0
7. ChinaXiv:202409.00180
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Recent progress in chemoenzymatic synthesis of human glycans

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-09-20

Ma, Shengzhou Gao, Jinhua Tian, Yinping Wen, Liuqing

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Hits 1441 Downloads 443 Comment 0
8. ChinaXiv:202409.00183
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A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer’s disease transgenic mice

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-09-20

Zhang, Jingjing Ren, Wenming Liu, Xiaohui Chen, Jingjing Zeng, Yuteng Xiang, Huaijiang Hu, Youhong Zhang, Haiyan

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Hits 1339 Downloads 463 Comment 0
9. ChinaXiv:202409.00181
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Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors

Subjects: Pharmaceutical Science >> Medicinal Chemistry submitted time 2024-09-20

Jin, Zechen Dai, Yang Ji, Yinchun Peng, Xia Duan, Wenhu Ai, Jing Zhang, Hefeng

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Hits 1282 Downloads 431 Comment 0
10. ChinaXiv:202406.00253
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Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism

Subjects: Pharmaceutical Science >> Biochemistry(Drug related) submitted time 2024-06-14

Huixu Feng Guobin Liu Luhan Li Xuelian Ren Yue Jiang Wanting Hou Ruilong Liu Kun Liu Hong Liu He Huang

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Hits 1845 Downloads 531 Comment 0
11. ChinaXiv:202406.00254
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Exploring the Molecular Therapeutic Mechanisms of Gemcitabine through Quantitative Proteomics

Subjects: Pharmaceutical Science >> Biochemistry(Drug related) submitted time 2024-06-14

Yue Jiang Xuelian Ren Jing Zhao Guobin Liu Fangfang Liu Xinlong Guo Ming Hao Hong Liu Kun Liu He Huang

Peer Review Status:Awaiting Review

Hits 1790 Downloads 555 Comment 0
12. ChinaXiv:202405.00110
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D3EGFR: a webserver for deep learning-guided drug sensitivity prediction and drug response information retrieval for EGFR mutation-driven lung cancer

Subjects: Pharmaceutical Science >> Drug Design submitted time 2024-05-13

Yulong Shi Chongwu Li Xinben Zhang Cheng Peng Peng Sun Qian Zhang Leilei Wu Ying Ding Dong Xie Zhijian Xu Weiliang Zhu

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Hits 2427 Downloads 739 Comment 0
13. ChinaXiv:202405.00081
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FXR activation remodels hepatic and intestinal transcriptional landscapes in non-alcoholic steatohepatitis

Subjects: Pharmaceutical Science >> Other Disciplines Subjects: Medicine, Pharmacy >> Pharmacology submitted time 2024-05-10

Yingquan WEN Ziyuan ZOU Guanguan ZHAO Mengjiao ZHANG Yongxin ZHANG Gaihong WANG Jingjing SHI Yuanyang WANG Yeyu SONG Huixia WANG Ruyue CHEN Dongxuan ZHENG Xiaoqun DUAN Yameng LIU Frank J GONZALEZ Jian-Gao FAN Cen XIE

Peer Review Status:Awaiting Review

Hits 3163 Downloads 754 Comment 0
14. ChinaXiv:202404.00367
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Decoding homodimerization and antidepressant recognition at the norepinephrine transporter

Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-04-27

Heng Zhang Yuling Yin Tianwei Zhang Canrong Wu Wen Hu Xinheng He Benxun Pan Sanshan Jin Qingning Yuan H. Eric Xu Yi Jiang

Peer Review Status:Awaiting Review

Hits 1933 Downloads 537 Comment 0
15. ChinaXiv:202311.00051
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Cryo-EM structures of adenosine receptor A3AR bound to selective agonists

Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-04-17

Hongmin Cai Shimeng Guo Youwei Xu Zhikan Xia Junrui Li Jun Sun Yi Jiang Xin Xie, H. Eric Xu

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Hits 2216 Downloads 608 Comment 0
16. ChinaXiv:202404.00153
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Impact of Halogen Bonds on Protein-Peptide Binding and Protein Structural Stability Revealed by Computational Approaches

Subjects: Pharmaceutical Science >> Drug Design submitted time 2024-04-10

Jintian Li Liping Zhou Zijian Han Leyun Wu Jianfang Zhang Weiliang Zhu Zhijian Xu

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Hits 2533 Downloads 1078 Comment 0
17. ChinaXiv:202403.00001
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Molecular basis of ligand recognition and activation of succinate receptor

Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-02-29

Changyao Li Heng Liu Jingru Li Haoran Zhu Wei Fu H. Eric Xu

Peer Review Status:Awaiting Review

Hits 2450 Downloads 786 Comment 0
18. ChinaXiv:202402.00231
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Reevaluating GPR30: A Paradigm Shift from Estrogen Receptor to Unique Hydrophilic Ligand Activation

Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-02-24

Heng Liu Shimeng Guo Antao Dai Peiyu Xu Xin Li Sijie Huang Xinheng He Kai Wu Xinyue Zhang Dehua Yang Xin Xie H. Eric Xu

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Hits 2238 Downloads 655 Comment 0
19. ChinaXiv:202402.00222
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Structural Insights into Ligand Recognition, Selectivity and Activation of the human Bombesin Receptor Subtype-3

Subjects: Pharmaceutical Science >> Structural Biology submitted time 2024-02-21

Youwei Xu Xinheng He Wenxin Su Jingru Li Xinzhu Li H. Eric Xu Wanchao Yin Changyao Li

Peer Review Status:Awaiting Review

Hits 2217 Downloads 769 Comment 0
20. ChinaXiv:202402.00168
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In Silico Off-Target Profiling for Enhanced Drug Safety Assessment

Subjects: Pharmaceutical Science >> Drug Design submitted time 2024-02-20

Jin Liu Yike Gui Jingxin Rao Jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu Zhiyi Chen Xia Sheng Yitian Wang Mingyue Zheng Xutong Li

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Hits 2312 Downloads 672 Comment 0

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